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Metrics to Evaluate PET Response to Therapy Based on 3D Analysis

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Document pages: 10 pages

Abstract: Thedisadvantage of visualizing tomography by slices is that an important attributeof the object, its volume, is not easily perceived or measured. In oncologythis creates a problem, which is addressed here: if early detection andresponse to treatment are an important prognostic element, then volume is important.The literature has proposed surrogates to volume derived from measures onslices, but geometrically they are not well founded. Actual volume analysis isnot complex, and the proposed method applies equally well to organs as totumors. Volume based measures are more sensitive than individual SUV values, ofwhich the commonly most used is the maximum Standardized Uptake Value (SUVm). If the tumor volume isdefined, it can be replaced by the total tumor SUV (SUVt). If themetric for change is the ratio after (before + after), in the patientpopulation analyzed here, the SUVm metric averages 0.132 forresponse and 0.662 for progression, the total SUVt range is 0.069 to0.734. In contrast to SUVt, SUVm is based on a weaksampling method since it is based on the value of a single voxel of more than10 million.

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