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Wide Applications of Chloroquine Other Than Antimalarial

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Document pages: 31 pages

Abstract: Chloroquine (CQ) was and still considered as the mostcommon agent in the treatment and prophylaxis of malaria, it also possesses many differentpharmacological and biological activities that make it able to be used as atherapy or adjuvant therapy for many types of diseases. CQ exhibits anticanceractivity alone or as adjuvants with other agents against many kinds of tumors.Its activities also were approved as an anti-inflammatory agent in rheumatoid and other autoimmune diseases likesystemic lupus and rheumatic arthritis. Its’ important role in the improvement of many metabolic disorders likehypertension, hyperglycemia, and lipid profile disturbances was alsoestablished. CQ can act against different microbial infections such as manytypes of viruses, bacteria and fungus by different mechanisms of action. Furthermore, itsdermatological role in the treatment of many skin diseases was demonstrated. Recently, CQ showed a veryresponsive role in curing and prevention of the covoid-19 virus. This review summarizes intensively the multipletherapeutic applications of CQ and discusses the possible mechanisms of actionfor these applications.

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