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Technical Considerations when using Verasonics Research Ultrasound Platform for Developing a Photoacoustic Imaging System

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Document pages: 28 pages

Abstract: Photoacoustic imaging (PAI) is an emerging functional and molecular imagingtechnology that has attracted much attention in the past decade. Recently, manyresearchers have used the Vantage Verasonics research system for simultaneousultrasound (US) and photoacoustic (PA) imaging. This was the motivation towrite on the details of US PA imaging system implementation andcharacterization using Verasonics platform. We describe the subtle details ofUS PA imaging system setup, study the performance parameters of the system, andexplain sequencing of the US PA signal generation and signal amplification aswell as the details required for efficient use of the hardware of the systemand data processing protocols. We focused on linear-array based PAI due to itspopularity and simple setup, as well as its high potential for clinicaltranslatability. We have shown the sequencing of the US PA signal generation,signal amplification, and related data processing protocols. A step-by-stepguideline to develop and characterize PAI system using Vantage 128 has beenpresented. Some of the limitations of the vantage system are also listed.Photoacoustic imaging is a complement to the already established US imagingtechnique and may significantly increase its scope of application in diagnosticimaging and therapeutic monitoring. Combining with commercial medical USsystems, the development of PAI can be accelerated by taking advantage of USimage reconstruction and processing. With the information we presented in thebody of this review and the four appendices, we described most of theexperimental considerations one should know when working with the Vantagesystem for PAI tests.

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