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Speckle illumination SFDI for projector-free optical property mapping

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Document pages: 8 pages

Abstract: Spatial Frequency Domain Imaging can map tissue scattering and absorptionproperties over a wide field of view, making it useful for clinicalapplications such as wound assessment and surgical guidance. This technique haspreviously required the projection of fully-characterized illuminationpatterns. Here, we show that random and unknown speckle illumination can beused to sample the modulation transfer function of tissues at known spatialfrequencies, allowing the quantitative mapping of optical properties withsimple laser diode illumination. We compute low- and high-spatial frequencyresponse parameters from the local power spectral density for each pixel anduse a look-up-table to accurately estimate absorption and scatteringcoefficients in tissue phantoms, in vivo human hand, and ex vivo swineesophagus. Because speckle patterns can be generated over a large depth offield and field of view with simple coherent illumination, this approach mayenable optical property mapping in new form-factors and applications, includingendoscopy.

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