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Antifungal and Cytotoxic Activities of Biosynthesized Silver, Zinc and Gold Nanoparticles by Flower Extract of Rhanterium epapposum

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Document pages: 12 pages

Abstract: This study was designed to prepare silver, zinc and gold nanoparticles(NPs), AgNPs, ZnNPs and AuNPs, by biosynthesis technique using methanolicextract of Rhanterium epapposum flowers using AgNO3, Zn (CH3CO2)2 and HAuCl4·3H2O as starting materials. The physicalproperties of the formed NPs were characterized by ultraviolet spectroscopy (UV),X-ray diffraction (XRD), transmission electron microscopy and Fouriertransformed infrared spectroscopy (FTIR). The results revealed that, AgNPs werehomogeneous and spherical in shape, with average diameter 16.3 nm. While, ZnNPswere approximately triangle and hexagonal shaped, with average diameter 23.5 nm.Most of the synthesized AuNPs were spherical in shape with average diameter17.9 nm. The antifungal activity of different concentrations of the formedAgNPs, ZnNPs and AuNPs was tested against two human pathogens: Candida albicans and Aspergillus melleus and one plant pathogenic fungus: Phoma exigua, using agar diffusionassay. The best results recorded by 120 μg ml AgNPs against the human pathogen: C. albicans where the inhibition zone was 23.5 mm.Additionally, the cytotoxicity of the tested NPs was evaluated against Breastadenocarcinoma (MCF-7), Hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT 116) human celllines. The most toxic was AuNPs where the IC50 against MCF-7, HepG2 and HCT116was 55.02, 66.44 and 169.87 μg mL respectively.

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