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Antioxidant and Antiplasmodial Activities of Extracts from Gardenia erubescens Stapf et Hutch. and Fadogia agrestis Schweinf. ex Hiern. (Rubiaceae)

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Document pages: 13 pages

Abstract: Two medicinal plants, Gardenia erubescens and Fadogia agrestis were selected to evaluate their biologicalactivities. Their total phenolic and flavonoid contents were assessed using folin-ciocalteu and aluminumchloride regents’ methods. The antioxidant activity was estimated using DPPH(1,1-diphényl-2-picrylhydrazyl), ABTS (2,2’-azinobis-[3-ethylenzothiazoline-6-sulfonicacid]) and FRAP (ferric reducing antioxidantpower). The antiplasmodial activity of the extracts wasdetermined in vivo on 42 NMRI mice. The results indicate that all the extractsfrom both two plants contain some polyphenols. The ethanolic extract of theleaves of Gardenia erubescens showed the best antioxidantactivity by the method of DPPH. The aqueous extracts of the leaves of Gardenia erubescens and the whole plant of Fadogia agrestis have areducing power similar to control (quercetin). All the extracts have a lowcapacity to scavenge the ABTS radical cation compared to the controls (troloxand quercetin). Concerning the antiplasmodial activity, all the extractspresented moderate antiplamodial activities. This result could justify thetraditional uses of Gardenia erubescens and Fadogia agrestis to treat of malaria in Burkina Faso.

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