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Oxidative Cascade Prognosis, Antioxidants & Selected Trace Elements in COVID-19

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Document pages: 13 pages

Abstract: COVID-19pandemic has now become a challenging global public health concern, havinghigher risk of developing fatal respiratory disease due to severe inflammatoryresponses associated with the virus-mediated oxidative stress. The respiratorysystem is most preferred target organ for this novel virus as the lung is welloxygenated and having large surface area available to the virus for exposureand successively augmenting the health complications. Oxidative stress (OS) isan important factor causing metabolic and physiological alteration and variousdisease augmentations within the body. Respiratory viral infection has generalconsociation with cytokine production, inflammation, cell death and otherpathophysiological processes which may be the result of perturbed redoxbalance. Apart from this, the presence of conditions likes aging, diabetes andhypertension and chronic obstructive pulmonary diseases (COPD) are the riskfactor for making severity of such infection outcome. It has been wellestablished that an overproduction of reactive oxygen species (ROS) and antioxidantmechanisms deprivation are vital step for viral replica production andconsequent release of pro-inflammatory cytokines is also an important factor of the innate immuneresponses to the pathogens that may result into acute lung damage. Additionally, ROS can damage variousvital biological molecules and inactivation of essential enzymes. Oxidativestress is an important factor causing metabolic and other pathophysiologicalalterations, suchas protein oxidations and various associated diseases. Therefore, in this paper, the significant adverseimpact of virus on host cell and underlying possible biochemical mechanism hasbeen discussed.

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