eduzhai > Physical Sciences > Physics Sciences >

Myocardial Segmentation of Area at Risk Based on Coronary Computed Tomography Angiography and Voronoi Diagram in Comparison with Magnetic Resonance Perfusion Imaging

  • Save

... pages left unread,continue reading

Document pages: 14 pages

Abstract: Purpose: To assess the clinical feasibility of automated segmentation of the myocardial area at risk (MAAR) using coronary computed tomography angiography (CT-MAAR), as compared to stress magnetic resonance myocardial perfusion imaging (MR-MPI). Materials and Methods: Thirty patients who underwent coronary computed tomography angiography (CTA) and stress MR-MPI were retrospectively evaluated. The myocardial territory of the left ventricle (LV) distal to coronary artery stenosis (≥50 or ≥70 stenosis on coronary CTA) was three-dimensionally quantified using a Voronoi diagram. The ratio of all stenosis-related territories to the LV volume was defined as CT-MAAR ( -LV volume). The proportion of segments with perfusion defects in stress MR-MPI to the total of 16 segments (range: 0 - 100 ; with a 6.3 -interval scale) was defined as the reference. Correlation was assessed using Spearman’s test. The capability of CT-MAAR to predict the ischemic burden was assessed. Results: Stress MR-MPI depicted a median ischemic burden of 25.2 (range: 18.9 - 44.1 ) in 30 patients without myocardial infarction. When CTA stenosis criteria of ≥50 (n = 30) and ≥70 (n = 27) were applied to estimate CT-MAAR, the median CT-MAAR values were 48.2 (31.6 - 64.3 ) and 32.5 (23.7 - 51.9 ), respectively. The correlations between the CT-MAAR values and the MR-based ischemic burden were significant (0.73 and 0.97 for ≥50 and ≥70 stenosis, respectively). CT-MAAR predicted the MR-based ischemic burden within ±1 segment of -LV (6.3 ) in 40 (12 30) of patients with ≥50 stenosis, and in 81.5 (22 27) of patients with ≥70 stenosis. Conclusions: Comprehensive assessment of resting coronary CTA combined with Voronoi diagram-based myocardial segmentation may help predict the myocardial ischemic burden in patients with severe coronary CTA stenosis.

Please select stars to rate!


0 comments Sign in to leave a comment.

    Data loading, please wait...