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An In-Vivo Study during Combined Intracavitary and Interstitial Brachytherapy of Gynaecological Malignancies Using microMOSFET

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Document pages: 13 pages

Abstract: Aim: To analyze the inter-fraction,intra-fraction uncertainties and to verify the delivered total dose withplanned dose in the combined intracavitary-interstitial brachytherapy ofgynaecological cancer patients using microMOSFET in-vivodosimeter. Materials and Methods: Between May 2014 and March 2016, 22 patientswho underwent brachytherapy treatments with an applicator combination of CT MRcompatible tandem, ring and Syed-Neblett template-guided rigid needles wereincluded in this study. Specially designed microMOSFET, after calibration, wasused to analyze the variations in dosimetry of combinedintracavitary-interstitial application. Results: The standard deviation forInter-fraction variation among 22 combined intracavitary interstitialapplications ranged between 0.86 and 10.92 . When compared with the firstfraction dose, the minimum and maximum dose variations were −9.5 and26.36 , respectively. However, the mean doses varied between −5.95 and 14.49 . Intra-fraction variation, which is the difference of TPS calculateddose with first fraction microMOSFET-measured dose ranges from −6.77 to 8.68 . The variations in the delivered total mean dose in 66 sessions withplanned doses were −3.09 to 10.83 . Conclusions: It is found thatthere was a gradual increase in microMOSFET measured doses as compared to thefirst fraction with that of subsequent fractions in 19 out of 22 applications.Tumor deformation and edema may be the influencing factors, but the applicatormovements played a major role for the variations. We find that the microMOSFETis an easy and reliable system for independent verification of uncertaintiesduring ICBT-ISBT treatments.

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