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Methodology for Constructing a Short-Term Event Risk Score in Heart Failure Patients

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Document pages: 21 pages

Abstract: We present a methodology for constructing a short-term event risk score inheart failure patients from an ensemble predictor, using bootstrap samples,two different classification rules, logistic regression and linear discriminantanalysis for mixed data, continuous or categorical, and random selection ofexplanatory variables to build individual predictors. We define a measure ofthe importance of each variable in the score and an event risk measure by anodds-ratio. Moreover, we establish a property of linear discriminant analysisfor mixed data. This methodology is applied to EPHESUS trial patients onwhom biological, clinical and medical history variables were measured.

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