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FEM Model of the Temperature Distribution in the Brain during Enhanced Infrared Neural Stimulation Using Nanoparticles

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Document pages: 13 pages

Abstract: Objectives: Enhanced infrared neuralstimulation (EINS) using nanoparticles is a new research hotspot. In thispaper, the numerical modeling of the interaction between a light source andbrain tissue during EINS is studied. Materials and Methods: This modelis built with the finite element method (FEM) to mimic the propagation andabsorption of light in brain tissue with EINS. Only the thermal change isconsidered in this model since the photothermal effect is the main mechanism ofEINS. The temperature response of brain irradiation is governed by theextensively used Pennes’ bio-heat equation in a multilayer model. Results: The temperature distribution in the brain under laser irradiation isdetermined. And the relationships between the brain tissuetemperature and the three factors (the laser pulse time, the laser energy andthe enhanced absorption coefficient of the tissue caused by the nanoparticles)are analyzed. Conclusions: The results indicate that the brain tissue is easierto warm up with the enhancement of nanoparticles and parameters of the lasercan alter the temperature increase of the brain tissue. These findings offera theoretical basis for future animal experiments.

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