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PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin

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Document pages: 18 pages

Abstract: Ofloxacin is an antibiotic with a wide range ofactivity against bacterial infections, but due to the high potential fortoxicity when exposed to light, resolving this problem and further stabilizingthe drug are among the posed challenges.Inclusion complex formation between α-cyclodextrin(α-CD), ofloxacin (OFL) andpolyethylene glycol (PEG) was prepared via two methods to produce nanocontainerswith desirable stability. The effect of PEG as compatiblesolubilizing agent and mixing condition (in ultrasonicbath) were investigated in formation ofan inclusion complex between α-CD OFL.Obtained complexes were examined by FTIR, H-NMR, SEM, EDX and UV which indicated the formation of aninclusion complex between α-CD OFL, in turn, is a mixture of the cage and channelstructures. Differences between 1H-NMR, FTIR and XRD spectra of OFL,CDs and inclusion complex indicated the formation of α-CD OFL and supramolecular containers in solid phase. These inclusion complexes loaded in PVA-basednanofibers for smart nanofibers with controlled release manner and higherstability of OFL. Obtained nanofiber showed that nanofibers containing CDs OFLunder sonic energy containing higherdegree of OFL.

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