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High baseline CD4 counts and exclusive breastfeeding are associated with lower maternal and child HIV transmission rates in northwestern Uganda: a two-year retrospective cohort study

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Document pages: 9 pages

Abstract: Background, according to the regulation of alternative B+, the spread of human immunodeficiency virus (HIV) along the early stage of HIV cascade diagnosis (EID) is still unknown. We described HIV transmission along the Eid cascade at the Arua regional referral hospital in northwestern Uganda and identified related factors. method. Data from 295 mother infant pairs in Eid care (January 2014 and April 2015) were extracted, cleaned and analyzed in Stata. Univariate, bivariate and multivariate analyses were performed. Independent related factors were expressed as adjusted odds ratio (AOR), 95 confidence interval (CI) and - value. Results 233 (89.0 ) mothers were over 30 years old, 251 (85.1 ) were in World Health Organization (who) clinical phase I II at school, and 170 (57.6 ) participated in prenatal care (ANC)ring recent pregnancy, and 204 (69.1 ) delivered in a health facility. Meanwhile, 257 (87.1 ) HIV Exposed Infants (HEIs) received Nevirapine prophylaxis from birth up to 6 weeks and 245 (83.0 ) were exclusively breastfed during the first 6 months. Of 295 mother-baby pairs, 25 (8.5 ) HEIs turned HIV-positive along the EID cascade. Baseline maternal CD4 count of more than 500 cells ul compared to less than 500 cells ul (adjusted odds ratio (AOR) = 0.29; 95 Confidence Interval (CI): 0.10–0.85; = 0.024) and exclusive breastfeeding (EBF) in the first 6 months of delivery in contrast to not EBF in the first 6 months (AOR = 0.17; 95 CI: 0.52–0.55; = 0.003) reduced HIV transmission. Meanwhile, ANC visits, place of delivery, time of Nevirapine initiation, and maternal antiretroviral therapy use were not significantly associated with infant HIV transmission. Conclusion. HIV transmission was high. High baseline CD4 count and exclusive breastfeeding reduced HIV transmission.

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