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Comparison of general practice and drug dispensing data in drug epidemiological studies: assessment of urinary tract infection risk in diabetic patients using sodium glucose co transporter 2 inhibitors

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Document pages: 7 pages

Abstract: Background study compares the results of a study conducted by the Australian general practice electronic health record database MedicineInsight, which is used to assess the risk of diabetes associated urinary tract infection by sodium glucose co transporter 2 inhibitor (SGLT2). The same study was conducted in 10 random samples from the national drug welfare plan data. method. The cohort study was conducted using unknown data from two national data sets. In each data set, the initiator of SGLT2 inhibitor was compared with that of dipeptidyl peptidase 4 (DPP-4) inhibitor from January 2012 to September 2015. The risk of urinary tract infection (UTI) was assessed at 6-month follow-up after the start of SGLT2 and DPP-4. Consequence: there are 1977 people in SGLT2 and SGLT1 people in the DPP-4 cohort (MedicineInsight data) and 3,120 in the SGLT2 and 12,359 in the DPP-4 cohort (10 PBS data). In both datasets, the risk of UTI after initiation of SGLT2 was not significantly increased in comparison to DPP-4 cohort (MedicineInsight: 3.6 versus 4.9 ; aHR=0.90, 95 CI 0.66-1.24; PBS: 3.0 versus 3.9 ; aHR=0.90, 95 CI 0.72-1.13, 10 ). Conclusions. Comparison of MedicineInsight data to PBS national pharmacy data demonstrated highly comparable results for the specific study question. MedicineInsight is a reliable source of data that can be used for pharmacoepidemiological studies.

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