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Determinants of active pulmonary tuberculosis after antiretroviral treatment in adult HIV positive patients in xizhaohe District Public Hospital of Ethiopia: a case-control study

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Document pages: 8 pages

Abstract: Introduction of tuberculosis is a major public health problem in the world, especially in sub Saharan Africa. Although the effect of antiretroviral therapy has improved, it is the most common opportunistic infection and the main cause of death of people infected with human immunodeficiency virus. Goals. The purpose of this study was to determine the determinants of active tuberculosis in adult HIV positive patients after antiretroviral treatment in xizhaohe district public hospital in Ethiopia. method. From February to June 2019, a multicenter unmatched case-control study was conducted in selected public hospitals in xizhaohe district. A total of 406 participants (203 cases and 203 controls) participated in the study. For adult HIV patients, tuberculosis occurred after ART started. controls were adult HIV patients who did not develop tuberculosis after ART initiation. Data were collected using interviewer administered structured questionnaire. Logistic regression analysis was performed using SPSS version 24 statistical software. Statistical significance test was set at 95 confidence level. Results. This study identified that patient’s previous TB history (AOR = 2.41; 95 CI: 1.49, 3.90; P value<0.001), haemoglobin level (AOR = 3.67; 95 CI: 1.98, 6.79; P value<0.001), CD4 cells count (AOR = 2.02; CI: 1.24, 3.29; P value=0.004), adherence level (AOR = 19.00; CI: 5.59, 64.59; P vaue<0.001), and WHO HIV AIDS clinical stage (AOR = 2.58; CI: 1.59, 4.18; P vaue<0.001) were found to be statistically significant determinants for the occurrence of tuberculosis among PLHIV after ART initiation. Conclusion. Patient’s previous TB history, haemoglobin level, CD4 cells count, adherence level, and WHO clinical stage were significant determinants of occurrence of tuberculosis after ART initiation in PLHIV.

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