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Determinants of intraocular pressure (IOP) in glaucoma patients at Bahir Dar felege hiwot referral hospital in Ethiopia

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Document pages: 7 pages

Abstract: Background glaucoma is the main cause of irreversible blindness in the world. It is related to the characteristic injury of optic nerve and the loss of visual field caused by degeneration of retinal ganglion cells. The main purpose of this study was to investigate the determinants of intraocular pressure changes in glaucoma patients treated at Bahir Dar felege hiwot referral hospital in Ethiopia. method. During the follow-up period from January 2014 to December 2018, a retrospective cohort study design was conducted on 328 glaucoma patients randomly selected from the hospital ophthalmology clinic. Glaucoma patients with two or more visits during the study period were included in the study, except those who took drugs less than twiceed from the study. A linear mixed-effects model for intraocular pressure change was used for data analysis. Result. The estimated coefficient of fixed effect intercept was 25.1829, which indicates that the average IOP of the patients was 25.1829 mmHg at baseline time by excluding all covariates in the model ( value <0.0001), age (=0.07, 95 CI 0.03, 0.11), urban residence ( = −1.60, 95 CI −2.84, −0.36), family history of glaucoma ( = 4.90, 95 CI 3.38–6.43), timolol and pilocarpine medication ( = −2.02, 95 CI −4.01, −0.03), cup-disk ratio >0.7 ( = 2.60, 95 CI 1.24–3.96), and follow-up time ( = −0.34, 95 CI −0.47, −0.21) were significantly associated with intraocular pressure of glaucoma patients. Conclusion. The predictor age, residence, family history of glaucoma, type of medication, cup-disk ratio, and follow-up time were significantly associated with the intraocular pressure of glaucoma patients. Therefore, healthcare providers give more attention and prioritize those identified factors and give frequent counseling about reducing intraocular pressure of glaucoma patients.

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