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Antifungal and antioxidant activities of pyrrolidone thiosemicarbazone complexes

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Document pages: 6 pages

Abstract: The metal complexes of (z) - 2 - (pyrrolidine-2-subunit) hydrazine thioamide (L) with Cu (II), CO (II) and Ni (II) chlorides were tested against selected types of fungi. It was found that it has significant antifungal activity. The free radical scavenging ability of metal complexes is determined by their interaction with the stable free radical 2,2 - diphenyl-1-picric acid hydrazine. All compounds show encouraging antioxidant activity. DFT calculation of copper complex was carried out by using the optimized molecular structure. Molecular orbital calculation provides a detailed description of the orbital, including spatial characteristics, node modes and the contribution of a single atom.

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