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Physicochemical properties and cellular response of strontium doped gypsum biomaterials

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Document pages: 9 pages

Abstract: This paper describes some physical, structural and biological properties of gypsum bioceramics doped with different amounts of strontium ions (0.19-2.23), and compares these properties with pure gypsum as a control. Strontium doped gypsum (gypsum: SR) is obtained by mixing hemihydrate calcium sulfate powder and strontium nitrate solution, and then washing the sample with distilled water to remove residual salt. Gypsum is the only phase found in the composition of pure and gypsum: Sr, and a shift to a lower diffraction angle is observed in the X-ray diffraction pattern of the doped sample. The microstructure of all gypsum samples is composed of many rod-shaped small crystals intertwined with each other. For gypsum, these crystals have greater elongation and higher thickness. The Sr-doped sample exhibited higher compressive strength and lower solubility than pure gypsum. A continuous release of strontium ions was observed from the gypsum:Sr during soaking it in simulated body fluid for 14 days. Compared to pure gypsum, the osteoblasts cultured on strontium-doped samples showed better proliferation rate and higher alkaline phosphatase activity, depending on Sr concentration. These observations can predict better in vivo behavior of strontium-doped gypsum compared to pure one.

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