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Synthesis, spectral characterization and in vitro antibacterial study of PYRIDINE-2-CARBOXYLIC acid n ′ - (4-chlorobenzoyl) - Hydrazine and its co (II), Ni (II) and Cu (II) complexes

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Document pages: 7 pages

Abstract: N-substituted pyridine hydrazides (pyridine-2-carbonyl chloride and 4-chlorobenzoic acid hydrazide) react with cobalt (II), nickel (II) and copper (II) metal salts in ethanol to form imino carbon nitrogen double bonds through hydrazide. According to elemental analysis, infrared spectrum, solid reflection spectrum, magnetic moment, molar conductivity and thermal analysis (TG). According to the elemental analysis data, 1  :   2 forms a metal complex with the general formula [mcl2 (HL) 2] · yh2o (where M = CO (II), Ni (II) and Cu (II), y = 1 – 3). The important infrared bands corresponding to active groups in ligands and solid complexes were studied. IR spectra showed that the ligand coordinated with metal ions in the form of neutral Bdentate manner with ON donor sites. The solid complexes have been synthesized and studied by thermogravimetric analysis. All the metal chelates are found to be nonelectrolytes. From the magnetic and solid reflectance spectra, the complexes (cobalt(II), nickel(II), and copper(II)) have octahedral and square planner geometry, respectively. The antibacterial and antifungal activity’s data show that the metal complexes have a promising biological activity comparable with the parent ligand against bacterial and fungal species.

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