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Synthesis and in vitro antitumor activity of Schiff base phenanthroline mixed ligand oxyvanadic acid (IV) complexes

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Document pages: 14 pages

Abstract: [VO (msatsc) (phen)], (1) (msatsc = methoxysalicylaldehyde thiosemicarbazone, phen = o-phenanthroline) and their new derivatives [VO (4-chlorosalt) (phen)], (2) (4-chlorosalt SC = 4-chlorosalicylaldehyde thiosemicarbazone) were synthesized and characterized by elemental analysis, IR, ES-MS and 1H NMR. Their antitumor effects on BEL-7402, Huh-7 and HepG2 cells were studied by MTT assay. Cell cycle analysis, Hoechst 33342 staining, annexin V-FITC PI assay and mitochondrial membrane potential were used( Δψ m) The antitumor biological mechanism of the two complexes in BEL-7402 cells was studied. The results showed that complex 1 and complex 2 significantly inhibited the growth of cancer cells, mainly by BL-7402 cells G0 G1 cell cycle arrest and induced apoptosis. Both 1 and 2 decreased significantly the ΔΨm, causing the depolarization of the mitochondrial membrane. Complex 2 showed greater antitumor efficiency than that of complex 1.

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