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Synthesis, characterization and bioactivity of novel organotin (IV) Schiff base complexes containing histidine derivatives

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Document pages: 12 pages

Abstract: Five new complexes of tin Schiff bases with histidine analogues (derived from the condensation of L-histidine with 3,5-di-tert-butyl-2-hydroxybenzaldehyde) were synthesized and characterized. Characterization   and 119Sn) and solid-state 119Sn NMR were completed by infrared spectroscopy, high-resolution mass spectrometry, 1D and 2D solution NMR (1H, 13C). Spectral evidence shows two types of structures: triangular biconical stereochemistry, in which the tin atom is coordinated with five donor atoms (two oxygen atoms, one nitrogen atom and two carbon atoms belong to the alkyl part), and one ligand molecule is coordinated in a tridentate manner. The second structure is described spectroscopically as a tetrahedral tin complex with four donor atoms (one oxygen atom)atom coordinated to the metal and three carbon atoms belonging to the alkyl or aryl substituents), with one molecule of ligand attached. The antimicrobial activity of the tin compounds has been tested against the growth of bacteria in vitro to assess their bactericidal properties. While pentacoordinated compounds 1, 2, and 3 are described as moderate effective to noneffective drugs against both Gram-positive and Gram-negative bacteria, tetracoordinated tin(IV) compounds 4 and 5 are considered as moderate effective and most effective compounds, respectively, against the methicillin-resistant Staphylococcus aureus strains (Gram-positive).

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