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The antibacterial activity of coated silver nanoparticles combined with antibiotics against Gram-negative and gram-positive bacterial models was enhanced

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Document pages: 7 pages

Abstract: The nanoparticles used in this study were prepared from AgNO3 with NaBH4 in the presence of capping agents such as citrate, sodium dodecyl sulfate and polyvinylpyrrolidone. The prepared nanoparticles were characterized by UV Vis, TEM and XRD. The appearance of yellow and the maximum absorption value between 399 and 404 confirmed the formation of silver nanoparticles. The prepared nanoparticles are spherical and polydisperse. For citrate, SDS and PvP coated nanoparticles, the average particle size iscin, ampicillin, and tetracycline) was evaluated on model Gram-negative and Gram-positive bacteria, employing disc diffusion assay. The activity of the tested antibiotics was enhanced in combination with all the stabilized nanoparticles, against both the Gram classes of bacteria. The combined effects of silver nanoparticles and antibiotics were more prominent with PVP capped nanoparticles as compared to citrate and SDS capped ones. The results of this study demonstrate potential therapeutic applications of silver nanoparticles in combination with antibiotics.

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