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Synthesis, characterization, electrochemical properties and in vitro bioactivity of Cu (II), Ni (II) and Zn (II) complexes with ester containing Salan ligands

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Document pages: 11 pages

Abstract: The reduced and N-alkylated salen ligand provides a new [N2O2] chelating ligand, which contains ester group [L = diethyl-2, - (propane-1,3-diacyl bis ((2-hydroxy-3-methoxybenzyl) azaalkynyl) diacetate]. The purity of the ligand was confirmed by nuclear magnetic resonance and high performance liquid chromatography. Its Cu (II), Ni (II) and Zn (II) were synthesized The complexes were characterized by elemental analysis, IR, NMR, UV Vis and mass spectrometry data and thermogravimetric analysis (TG DTA) Square planar geometry around ions. Tetrahedral geometry was observed in TETRA coordinated zinc containing a large number of N-alkylated Salan ligands. The redox properties of copper complexes in dimethyl sulfoxide were studied by cyclic voltammetry. The voltammogram shows quasilarersible process. The interaction of metal complexes with CT DNA was investigated by UV-Vis absorption titration, ethidium bromide displacement assay, cyclic voltammetry methods, and agarose gel electrophoresis. The apparent binding constant values suggest moderate intercalative binding modes between the complexes and DNA. The in vitro antioxidant and antimicrobial potentials of the synthesized compounds were also determined.

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