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Study on drug release of porous hollow silica nanospheres in vitro ZnS@SiO2 Core shell

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Document pages: 6 pages

Abstract: In this contribution, porous hollow silica nanoparticles were prepared using inorganic nano ZnS as template. Pure ZnS nanospheres were synthesized by hydrothermal method. this ZnS@SiO2 Core-shell nanocomposites were prepared by a simple sol-gel method. Hollow silica nanostructures are achieved by selective removal of ZnS nuclei. The morphology, structure and composition of the product were determined by powder X-ray diffraction (XRD), emission scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR). The results show that the pure ZnS Nanoparticles are spherical with an average particle size of 40   corresponding to the blend structure of zinc. Porous Hllow silica nanoparticles obtained were exploited as drug carriers to investigate in vitro release behavior of amoxicillin in simulated body fluid (SBF). UV-visible spectrometry was carried out to determine the amount of amoxicillin entrapped in the carrier. Amoxicillin release profile from porous hollow silica nanoparticles followed a three-stage pattern and indicated a delayed release effect.

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