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Synthesis, spectral characterization and antibacterial study of Schiff base metal ion complexes containing aliphatic and aromatic hydrazides

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Document pages: 10 pages

Abstract: The ethanol solution of 3-ketobutyryl hydrazide and salicylhydrazide was refluxed at an equal molar ratio to form the corresponding Schiff base LH3 (1). The latter reacts with Mn (II), CO (II), Ni (II), Cu (II), Zn (II), CD (II), Zr (OH) 2 (IV), MoO2 (VI) and UO2 (VI) ions in equal molar ratio to form corresponding complexes [M (LH) (MeOH) 3] (2, M = Mn, Co, Ni), [Cu (LH)] 2 (3), [M (LH) (MeOH)] (4, M = Zn, CD), [Zr (OH) 2 (LH) (MeOH) 2] (5), [MoO2 (LH) (MeOH)] (6) and [UO2 (MeOH)] (7). The complexes were characterized by elemental analysis, molar conductance, spectroscopy (IR, reflectivity, 1H NMR, ESR) and magnetic susceptibility measurement. They are non electrolytes in DMSO. Except 3, the complexes are diphenyl monomers. They are actively opposed to gam-positive bacteria (S. aureus, B. subtilis), gram-negative bacteria (E. coli, P. aeruginosa), and yeast (S. cerevisiae, C. albicans). 1 acts as a dibasic tridentate ONO donor ligand in 2–7 coordinating through its both enolic O and azomethine N atoms. The coordination compounds 2 and 3 are paramagnetic, while rest of the compounds are diamagnetic. A square-planar structure to 3, a tetrahedral structure to 4, an octahedral structure to 2, 6, and 7, and a pentagonal bipyramidal structure to 5 are proposed.

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