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Coordination kinetics and mechanism of new anticoagulant diethyl citrate with calcium ion

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Document pages: 8 pages

Abstract: Diethyl citrate (et2cit) is a potential new anticoagulant. The coordination kinetics and mechanism of et2cit with Ca2 + ions and the effect of pH value on the complexes were investigated. The results were compared with those of conventional anticoagulant sodium citrate (na3cit). The reaction order (n) of et2cit and na3cit with Ca2 + is 2.46 and 2.44 respectively. The reaction rate constants (k) are 120 and 289   L · mol − 1 · s − 1, respectively. The reverse reaction rate constants () are 0.52 and 0.15   L · mol − 1 · s − 1, respectively. The results show that the coordination ability of et2cit with Ca2 + is weaker than that of na3cit. However, the dissociation rate of calcium complex of et2cit is faster than that of na3cit. The increase of pH value accelerated the dissociation rate of the complex and improved its anticoagulant activityfect. The Et2Cit complex with calcium was synthesized and characterized by elemental analysis, XRD, FT-IR, 1H NMR, and ICP. These characteristics indicated that O in –COOH and C–O–C of Et2Cit was coordinated with Ca2+ in a bidentate manner with 1 : 1 coordination proportion; that is, complex CaEt2Cit was formed. Given that CaEt2Cit released Ca2+ more easily than Na3Cit, a calcium solution was not needed in intravenous infusions using Et2Cit as anticoagulant unlike using Na3Cit. Consequently, hypocalcemia and hypercalcemia were avoided.

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