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Synthesis and characterization of a novel palladium (ⅱ) thiosemicarbazone complex and its killing activity against a variety of tumor cells

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Document pages: 12 pages

Abstract: [PD (tsc1-5) 2] (6-10) palladium (II) double chelate complex and its corresponding ligands 4-Phenyl-1 - (acetone) - thiosemicarbazone, htsc1 (1), 4-Phenyl-1 - (2 - chlorobenzaldehyde) - thiosemicarbazone, htsc2 (2), 4-Phenyl-1 - (3 - hydroxybenzaldehyde) - thiosemicarbazone, htsc3 (3), 4-Phenyl-1 - (2 - NAPHTHALDEHYDE) - thiosemicarbazone were synthesized- The molecular structures of htsc3, htsc4 and [PD (TSC1) 2] (6) were determined by single crystal X-ray crystallography. Complex 6 has a square plane geometry, and two deprotonated ligands coordinate with complex 6atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (–9.87 M) exhibited higher antiproliferative activity than their free ligands (–70.86 and >250 M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 M, resp.).

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