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Synthesis, characterization and antibacterial study of transition metal (II) complexes of cefotaxime Schiff Base

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Document pages: 17 pages

Abstract: A new [ML2 (H2O) 2] complex, in which m   =   in ethanol medium, in the presence of divalent metal salt, cefotaxime and salicylaldehyde were condensed in situ to synthesize CO (II), Ni (II), Cu (II) and Zn (II), l corresponding to Schiff base ligand. The complexes were characterized by elemental analysis, conductivity and magnetic measurements, infrared and UV-vis spectra. The low value of molar conductance indicates that the complex is of non electrolyte type. According to the spectral data and magnetic moment, CO (II), Ni (II) and Zn (II) complexes may present octahedral configuration, while Cu (II) complexes may present tetragonal configuration. The molecular structures of Schiff base ligands and their complexes were studied by chemical simulation and quantum molecular calculation programion of chemical properties. All the synthesized complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.

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