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Synthesis, spectral characterization and anti proliferation of adamantine mixed titanium complexes

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Document pages: 12 pages

Abstract: Titanium complexes were synthesized by the reaction between titanium tetrachloride (TiCl4) and corresponding bidentate ligands [4,4 C50 value of 4.06 µM. Furthermore, the effect of synthesized complexes was studied on different stages of the cell cycle in CHO cells. All complexes exhibited the dose dependent increase in cytotoxicity. The results have shown an increase in sub-G0 population with increase in concentration which is an indicative measure of apoptosis.

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