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Synthesis, spectral characterization and bioactivity of some new axially linked indium (ⅲ) macrocyclic complexes

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Document pages: 7 pages

Abstract: The synthesis and spectral characterization of a novel axial ligand indium porphyrin complex are reported. Indium chloride porphyrin with high yield was obtained by treating the corresponding free base with indium trichloride. The effects of different phenolic compounds on chlorinated derivatives (tppin CL) lead to corresponding phenolic complexes (tppin-x). These derivatives were characterized by mass spectrometry, 1H-NMR, IR and UV-vis spectra. The separation and separation of these derivatives were achieved by chromatography. The spectral properties of free alkali porphyrins and their corresponding metallized and axially connected indium porphyrins were compared. The detailed analysis of UV-Vis, 1H NMR and IR spectra shows that the method has good stabilityformation from free base porphyrin to indium(III) porphyrin. Besides, 13C-NMR and fluorescence spectra were also reported and interpreted. The stability of these derivatives has also been studied through thermogravimetry. The complexes were also screened for anticancerous activities. Among all the complexes, 4-MePhO-InTPP shows highest anticancerous activity. The title complexe, TPPIn-X (where X = different phenolates), represents a five-coordinate indium(III) porphyrin complex in a square-pyramidal geometry with the phenolate anion as the axial ligand.

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