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Potential and plasma simulation of polyamino pentadentate ligand nickel (II) complex: Computer Aided metal drug design

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Document pages: 7 pages

Abstract: The thermodynamic equilibria of nickel (II) with N, n - bis (aminoethylene) - 2,6-pyridine dicarbonamide (L1), bis - (n, n-dimethylethyl) - 2,6-pyridine dicarbonamide (L2) and N, n - bis [2 (2-pyridyl) - methyl] pyridine-2,6-dicarbonamide (L3) at 25 ℃ and 0.15 ionic strength were studied by glass electrode potentiometry. The protonation and formation constants added to the plasma model predict that Cu (II) effectively competes with Ni (II), Zn (II) and Ca (II) for these ligands in vivo.

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