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Synthesis, characterization, semi empirical and biological activity of organotin (IV) carboxylates containing 4-piperidine carboxylic acid

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Document pages: 11 pages

Abstract: The organotin (IV) carboxylates   =   me (1), n-Bu (2), pH (3)] and r3snl [R   =   with the general formula r2sn (CL) l [R] reacted with KOH and r2sncl2 (R) by 4-piperidine carboxylic acid (HL), and synthesized me (4), pH (5)]   =   me, n-Bu, pH) r3sncl (R   =   me, pH in methanol under stirring conditions). The metal ligand binding sites, structure and stability of the complexes were confirmed by FT-IR, (1H, 13C) NMR, EI-MS and semi empirical studies. FT-IR data show the bidentate chelation mode of carboxylic acid ligands, which is also confirmed by semi empirical studies. In the solution state, the five and four coordination geometries around tin were confirmed by NMR. The EI-MS data are consistent with the molecular structure of the complex. Thermodynamic parameters and molecular descriptiontors were calculated by using semiempirical PM3 method. HOMO-LUMO calculations show that chlorodiorganotin complexes are more susceptible to nucleophilic attack as compared to triorganotin complexes. Computed negative heat of formation indicates that complexes 1–4 are thermodynamically stable. The organotin(IV) carboxylates displayed powerful antimicrobial activities against various strains of bacteria and fungi and their minimal inhibitory concentration were also evaluated. The complexes exhibited comparatively higher hemolytic activity as compared to free ligand.

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