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Synthesis, spectra, molecular structure and antibacterial properties of phenylalanine, isoleucine and glycine dibutyltin (IV) Schiff Base Complexes

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Document pages: 12 pages

Abstract: 1H indole-2,3-dione, 5-chloro-1h-indole-2,3-dione and α- A series of new organotin (IV) complexes and amino acid Schiff bases were designed and synthesized from amino acids (phenylalanine, isoleucine and glycine). All compounds were characterized by elemental analysis, molar conductance measurement and molecular weight determination. The bonding of these complexes was discussed by UV-vis, IR and NMR (1H, 13C and 119Sn NMR). The results show that Schiff base is a monobasic bidentate ligand and coordinated with dibutyltin (IV) in octahedral configuration according to the general formula [bu2sn (L) 2]. Elemental analysis and NMR data of ligands and their dibutyltin (IV) complexese with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus, Staphylococcus spp.) and Gram-negative (E. coli, Klebsiella spp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

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