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Antioxidant enzyme inhibitors of phosphine metal complexes in lung and leukemia cell lines

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Document pages: 10 pages

Abstract: Phosphine metal complexes have recently been evaluated in the field of cancer treatment. In this study, MTT assay was used to study the cytotoxicity of some metal phosphines [PdCl2 ((CH2OH) 2pch2) 2nch3] (C1), [rucl2 ((CH2OH) 2pch2) 2nch3) 2] (C2), [PtCl2 ((ph2pch2) 2nch3) (Timin) 2] (C3) on K562 (human myeloid leukemia cell line) and A549 (adenocarcinoma human alveolar basal epithelial cells). C1 and C2 are water-soluble metal complexes, which may have some advantages in vitro and in vivo studies. The effects of the above metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPX) (EC: 1.11.1.9) and catalase (CAT) (EC: 1.11.1.6) were also tested. The results of this study show that all three metal complexes showd dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.

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