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Electron paramagnetic resonance study of heat treated bismuth gallate

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Document pages: 9 pages

Abstract: The complexes of anti-inflammatory drug bismuth were studied by electron paramagnetic resonance spectroscopy. The purpose of this study is to determine the concentration and properties of free radicals formed by bismuth gallate during thermal sterilization according to pharmacopoeia specifications, so as to optimize its sterilization process. Different temperatures (160 ℃, 170 ℃ and 180 ℃) and sterilization time (120 minutes, 60 minutes and 30 minutes) were used. The interaction between bismuth gallate and DPPH (model radical reference) was examined - factor, amplitude (), integral intensity () and linewidth () were obtained. The integral strength is obtained by the double integral of the first derivative EPR line. The effect of microwave power in the range of 2.2-70   the effect of molecular weight on the shape and parameters of EPR spectrum was studiedxamined. Thermal sterilization produced free radicals in bismuth subgallate in all tested cases. Strong interactions with free radicals were pointed out for all the analysed samples containing bismuth independent of sterilization conditions. Optimal conditions of thermal sterilization for bismuth subgallate with the lowest free radical formation are temperature 170°C and time of heating 60 minutes. Strong dipolar interactions exist in thermally sterilized bismuth subgallate. EPR spectroscopy is a useful method of examination of thermal sterilization conditions.

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