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Gadolinium (III) complexes with n-alkyl-n-methylglucosamine surfactants are incorporated into liposomes as potential MRI contrast agents

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Document pages: 8 pages

Abstract: The complexes of gadolinium (III) with N- octyl -N- methyl glucosamine (L8) and N- decyl -N- methyl glucosamine (L10) were synthesized by 2 stoichiometry and characterized by elemental analysis, electrospray ionization tandem mass spectrometry (ESI-MS), infrared spectroscopy (IR) and molar conductivity measurements. The transverse () and longitudinal () relaxation protons   were measured at 20 ℃ and compared with commercial ones. These complexes were incorporated into liposomes, resulting in an increase in vesicle zeta potential. Compared with the commercial contrast agent Magnevist, both free and liposome doped gadolinium complexes showed higher relaxation effect. The high relaxation of these complexes is attributed to the molecular structureotation that occurs more slowly, because of the elevated molecular weight and incorporation in liposomes. The results establish that these paramagnetic complexes are highly potent contrast agents, making them excellent candidates for various applications in molecular MR imaging.

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