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Synthesis, characterization, anticancer and antioxidant properties of ruthenium (ⅲ) complexes with monobasic tridentate Schiff Bases

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Document pages: 11 pages

Abstract: [Ru (LL) Cl2 (H2O)] (ll = monobasic tridentate Schiff base anion: (1z) - n ′ - (2 -- [1 - (2,4-dihydroxyphenyl) ethylidene] ethyl) - n-phenylacetamide [DAE], 4 - [(1E) - N -- [(z) - (4-hydroxy-3-methoxybenzylidene) amino] ethyliminyl] benzene-1,3-diol [HME], 4 - [(1E) - N -- [(z) - (3,4-dimethoxybenzylidene) amino] ethyliminyl] Benzene-1,3-diol [MBE] and N - (2 - (2,4-dihydroxyphenyl) ethylidene] ethyl) benzoxyoxime chloride [Dee] were synthesized and characterized by microanalysis, conductivity measurement, electronic spectroscopy and FTIR spectroscopy. Infrared spectroscopy confirmed that the ligand, as a tridentate chelate, coordinated with metal ions through imine nitrogen and phenol oxygen atoms. Octahedral geometry has been proposed for all Ru (III)-chiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50 valves of , , and  μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)].

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