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Polyanionic biopolymer for transport of Pt (II) cationic antiproliferative complex

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Document pages: 7 pages

Abstract: Phenanthroline, that is, (sp-4-3) - diamine chloro (phenanthridine) platinum nitrate (II), an effective antitumor cationic platinum (II) complex, is loaded on negatively charged dextran sulfate (DS) as a model carrier for drug delivery through electrostatic interaction. Free complexes and corresponding conjugates to DS were tested on two standard human tumor cell lines, namely ovarian A2780 and colon HCT 116, and several malignant pleural mesothelioma cell lines, namely epithelioid br95, mixed biphasic mg06, sarcomatoid mm98 and sarcomatoid cisplatin resistant mm98r. The results in vitro showed that the conjugate released the active metabolite phenanthroline platinum in a biphasic manner. Under these experimental conditions, the activity of conjugates was slightly lower than that of free ferlatin; Daily minute both exhibited antiproliferative potency higher than the reference metallodrug cisplatin and were able to overcome the acquired cisplatin chemoresistance in MM98R cells.

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