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Synthesis and antibacterial activity evaluation of ruthenium (ⅲ) mixed complexes containing 1,10-phenanthroline and guanidine

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Document pages: 9 pages

Abstract: Two ruthenium (Ⅲ) complexes ([Ru (phen) 2Cl2] Cl · 2H2O and [Ru (phen) 2 (g) Cl] 2Cl · H2O) were synthesized from 1,10-phenanthroline and guanidine. The synthesis was examined using halide test, conductivity measurement and spectral (ICP-OES, FTIR and UV VIS) analysis. The in vitro antibacterial activities of two Gram-positive bacteria (Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA)) and two Gram-negative bacteria (E.coli and K.pneumoniae)) were also studied. These complexes also showed extensive and better activity against the most drug-resistant Klebsiella pneumoniae compared with commercially available controls (chloramphenicol and ciprofloxacin). [Ru(phen)2(G)Cl2Cl·H2O inhibited S. aureus, MRSA, E. coli, and K. pneumoniae by 17.5 , 27.4 , 16 , and 52 , respectively, better than Chloramphenicol. It also inhibited these pathogens by 5.9 , 5.1 , 2.3 , and 17.2 , respectively, better than Ciprofloxacin. Similarly, [Ru(Phen)2(Cl)2]Cl·2H2O inhibited these pathogens by 11 , 8.7 , 0.1 , and 31.2 , respectively, better than Chloramphenicol. Therefore, after in vivo cytotoxicity investigations, these compounds can be considered as potential antibiotic drugs.

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