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Synthesis, characterization, resolution and biological study of complexes of aspartic acid and glycine

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Document pages: 15 pages

Abstract: Racemic mixtures of enantiomeric aspartic acid coordination compounds and coordination compounds with glycine metal coordination ratio of 1  :   3 were synthesized and characterized by infrared and UV-vis spectrophotometry and magnetic susceptibility measurement. Five complexes were resolved using (+) - CIS dichlorobis (ethylenediamine) cobalt chloride (III), (+) - bis (glycine) (1,10-phenanthroline) cobalt chloride (III) and (+) - tris (1,10-phenanthroline) nickel chloride (II) as resolution agents. The antibacterial and cytotoxic activities of these complexes were then determined. The results showed that aspartic acid and glycine coordinated in a bidentate manner. The enantiomeric purity of the compound is 22.10-32.10 , in which (+) - CIS dichlorobis (ehylenediamine)cobalt(III) complex as the more efficient resolving agent. The resolved complexes exhibited better activity in some cases compared to the parent complexes for both biological activities. It was therefore inferred that although the increase in the lipophilicity of the complexes may assist in the permeability of the complexes through the cell membrane of the pathogens, the enantiomeric purity of the complexes is also of importance in their activity as antimicrobial and cytotoxic agents.

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