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Effect of the number of axial besarotene ligands on the cytotoxicity of oxaliplatin (IV) analogues

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Document pages: 6 pages

Abstract: We introduced the synthesis and cytotoxic efficacy of a new platinum (IV) complex with besarotene, an anticancer drug that induces cell differentiation and apoptosis through selective activation of retinoic acid X receptor. Among these complexes, besarotene is located as an axial ligand. A complex with one besarotene ligand attached to the Pt (IV) oxaliplatin moiety is effective, while its counterpart carrying two besarotene ligands is ineffective.

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