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Synthesis and cytotoxicity evaluation of steroidal copper (Cu (II)) complexes

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Document pages: 6 pages

Abstract: Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by condensation of sterone with thiosemicarbazone or diazo pyridine, and then complexation with steroidal thiosemicarbazone or diazo pyridine with copper (ⅱ). The complexes were characterized by IR, NMR and HRMS. The synthesized compounds were used to screen HeLa, BEL-7404 and 293T cell lines for cytotoxicity in vitro. The results showed that all steroidal copper (II) complexes had obvious antiproliferative activity against the detected cancer cells. The IC50 values of complexes 5 and 12 for BEL-7404 (human liver cancer) were 5.0 and 7.0   respectively μ M。

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