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Gloriosa superba mediated platinum palladium nanoparticles induce apoptosis in breast cancer cells

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Document pages: 9 pages

Abstract: In the past decade, green chemical methods for designing therapeutic nanodrugs have attracted considerable attention. In this paper, we report for the first time the anticancer potential of plant-derived platinum nanoparticles (ptnps) and palladium nanoparticles (pdnps) using the medicinal plant Glorisa superba tuber extract (GSTE). The synthesis of nanoparticles was completed within 5 hours at 100 ° C, which was confirmed by the dark brown and black of ptnps and pdnps and the enhancement of the peak intensity of UV-Vis spectrum, respectively. High resolution transmission electron microscopy (HRTEM) showed that the size range of monodisperse spherical nanoparticles was less than 10   nm. The elemental composition was confirmed by energy dispersion spectroscopy (EDS)ion, while dynamic light scattering (DLS) helped to evaluate the hydrodynamic size of the particles. Anticancer activity against MCF-7 (human breast adenocarcinoma) cell lines was evaluated using MTT assay, flow cytometry, and confocal microscopy. PtNPs and PdNPs showed 49.65 ± 1.99 and 36.26 ± 0.91 of anticancer activity. Induction of apoptosis was most predominant in the underlying mechanism which was rationalized by externalization of phosphatidyl serine and membrane blebbing. These findings support the efficiency of phytogenic fabrication of nanoscale platinum and palladium drugs for management and therapy against breast cancer.

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