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Synthesis, characterization and antibacterial activity of novel copper sulfonated triazine complexes

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Document pages: 7 pages

Abstract: Metal triazine complexes have interesting biological and medical properties. This study focuses on the synthesis, characterization and antibacterial activity of four new copper triazine derivatives in order to find effective antibacterial and antifungal drugs. In this study, 3 - (2-pyridyl) - 5,6-diphenyl-1,2,4-triazine-4,4 - disulfonic acid monosodium salt (L1, ferozine) and 3 - (2-pyridyl) - 5,6-bis (2-furanyl) - 1,2,4-triazine-5,5 - disulfonic acid disodium salt (L2, Ferene) were used as ligands to study the complexation of copper (II). The synthesized complexes [CuCl2 (FerroZine)] · 7H2O · MeOH (1), [CuCl2 (FerroZine) 2] · 5H2O · MeOH (2), [CuCl2 (ferrene)] · H2O · MeOH (3) and [CuCl2 (ferrene) 2] · H2O · MeOH (4) were characterized by spectroscopy and preliminary bioassayried out. FTIR spectroscopic data have shown that N=N and C=N stretching frequencies of complexes have been shifted towards lower frequencies in comparison with that of the ligands, confirming new bond formation between Cu and N, which in turn lowers the strength of N=N and C=N bonds. In addition, a bathochromic shift has been observed for UV-visible spectra of complexes (1), (2), (3), and (4). Furthermore, elemental analysis data have been useful to obtain empirical formulas of these complexes and to establish the purity of each complex. Complexes (1) and (2) have shown antibacterial activity for both S. aureus (ATCC® 25923) and E. coli (ATCC® 25922) at 1 mg disc concentration, and ferrozine has shown a larger inhibition zone against the clinical sample of C. albicans at 1 mg disc concentration in comparison with the positive control, fluconazole.

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