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Response of pulp dentin complex, PDL and bone to three calcium silicate based bone cements: histological study of animal rat model

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Document pages: 12 pages

Abstract: Objectively, the purpose of this study was to histologically examine the tissue response of three different calcium silicate bone cements in the closure of incisor perforation in rats. Materials and methods. The lateral root perforation experiment with pulp exposure was carried out on 32 lower incisors of 16 male Wistar albino rats. They were randomly divided into three test groups (each test group included eight teeth) filled with biodentine (BD) or micromega mineral trioxide aggregate (mm-mta) or endosequence root repair material putty (esrrm putty), and the other four rats (control group) had eight unperforated front teeth. The inflammatory response and healing process were evaluated histologically and scored after 1 and 4 weeks. The difference between groups was tested by Kruskal walis tests at . Results. In the first week, BD produced more inflammatory response in the pulpal (score 3) than other materials (score 2). Only ESRRM putty showed odontoblast-like cells in 50 , 25 dentine-like deposit, 25 evidence of bone deposition in the drilling site (score 2), and minimum periodontal ligament (PDL) necrosis and disorganization (25 , score 2). After one month, all groups had healthy pulpal tissue, but 25 of ESRRM putty retained score 1 inflammatory response, and 50 of the BD case had an incomplete palisading odontoblast layer (score 3). A thick and regular dentine bridge deposition was seen in the ESRRM putty group in comparison with MM-MTA and BD cases. The cortical plate healing in all ESRRM putty samples was complete (score 3), while an incomplete closure was seen in MM-MTA and BD groups (score 2). Both the MM-MTA and ESRRM putty groups had fully organized PDL (score 2), while in 50 of BD cases, a necrotizing area and disorganized PDL with inflammatory cells infiltration were still present. Statistically significant differences in the scores of any histologic parameters among the three tested materials were observed neither in the 1st nor in the 4th weeks of the experimental period. Conclusion. Better tissue compatibility and repair of pulpal and periodontal tissue have been detected after lateral perforation in the root of rat incisors when treated with ESRRM putty than MM-MTA and BD. However, the difference was not significant.

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