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Antibacterial activity and DNA / BSA binding affinity of polynuclear silver (I) complexes with 1,2-bis (4-pyridyl) ethane / ethylene as bridging ligands

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Document pages: 12 pages

Abstract: Polynuclear silver (I) complexes, {[Ag (BPA)] No3} n (1), {[Ag (BPA) 2] cf3so3. H2O} n (2) and {[Ag (BPE)] cf3so3} n (3) were synthesized from 1,2-bis (4-pyridyl) ethane (BPA) and 1,2-bis (4-pyridyl) ethylene (BPE). In complexes 1-3, the corresponding nitrogen-containing heterocycles act as bridging ligands between two Ag (I) ions. The in vitro antibacterial activity of these complexes and the ligands used to synthesize them were evaluated against a wide range of gram-positive and Gram-negative bacteria and fungi. Compared with other studied strains, silver (I) complexes 1-3 showed selectivity to Candida and gram-negative Escherichia coli, could effectively inhibit the growth of four different Candida species, and had the lowest inhibitory concentration (MIC)n 2.5 and 25 μg mL and the growth of E. coli, with MIC value being 12.5 μg mL. Importantly, complex 2 significantly reduced C. albicans filamentation, an essential process for its pathogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1–3. The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.

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