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Preparation of rutin silver nanoparticles and its safety, biological activity, immune regulation, anticancer and insecticidal potential

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Document pages: 11 pages

Abstract: Rutin belongs to Rutaceae, which is traditionally used as medicinal plants and food flavoring agents. The purpose of this study was to prepare silver nanoparticles (AGNPS) from ethanol extract of Sophora flavescens leaves, and to test the different biological activities and insecticidal potential of the extract and AgNPs prepared by the extract. Dried and powdered red moss leaves were extracted with ethanol and used to synthesize AgNPs. The synthesis of AgNP was monitored by color change, UV spectrophotometry and electron microscope (scanning). Fourier transform infrared spectroscopy (FT-IR) was used to monitor the functional groups in the extract. Its immunological, physiological, anticancer, antibacterial and insecticidal potentialextract and its prepared AgNPs were tested. Results showed the ability of the leaf extract to synthesize. SEM examination revealed a spherical shape of AgNPs with a size of 40–45 nm. The extract contained many functional groups as indicated by FT-IR. The extract alone inhibited the growth of normal rat splenic cells, while the extract containing AgNPs stimulated its growth. Extract alone stimulated HeLa cell proliferation and inhibited HepG2 growth, while both cell line growth was inhibited by the extract containing AgNPs. Both the extract and extract with AgNPs were safe on RBCs and did not cause any severe elevation in liver enzymes. The extract alone and with AgNPs showed insecticidal activity against Culex pipiens. Our findings suggest that the R. graveolens leaf extract, alone or with AgNPs, is biologically safe on animal cells and has antibacterial, insecticidal, and immunomodulation potentials.

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