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Synthesis, crystal structure, antibacterial and antitumor properties of two zinc (II) complexes containing pyridine thiazole derivatives

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Document pages: 9 pages

Abstract: Two pyridine thiazole derivatives, namely 4 - (pyridin-2-yl) - 2 - (2 - (pyridin-2-ylmethylene) hydrazinyl) thiazole (L1) and 4 - (pyridin-3-yl) - 2 - (2 - (pyridin-4-ylmethylene) hydrazinyl) thiazole (L2), were synthesized by α- The cyclization reaction between haloketones, thioamides and their Zn (II) was provided. The complexes were prepared by the reaction of ligands with corresponding metal salts and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in monoclinic system. The in vitro antibacterial activities of zinc (II) complexes and ligands were screened by microplate reading method, and the in vitro antitumor activities of the complexes were evaluated by MTT method in order to develop new and improved bioactive materials with new propertieses. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.

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