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Synthesis of novel zinc (ⅱ) and cadmium (ⅱ) Schiff base complexes and their biological evaluation as antibacterial, antifungal and antioxidant

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Document pages: 17 pages

Abstract: (E) - N, N-dimethyl-2 - ((E-1 - (2 - (p-tolyl) hydrazone) propane-2-subunit) hydrazine-1-thioamino (dmpthp) and its zinc (II) and cadmium (II) The complexes were synthesized and characterized. Different analytical tools such as elemental analysis, IR, mass spectrometry and 1H-NMR measurements were used to clarify the structure of the synthesized compounds. According to these spectral results, dmpthp ligands showed tridentate anions with single negative charge. The protonation constants of new Schiff base (dmpthp) ligands and their interactions with CD (II) and Zn (II) were studied and discussed by modeling and docking The formation constant of ions in 50 DMSO solution at 15 ℃, 25 ℃ and 35 ℃ at I   =   0.1   mol · min − 3.3. The solution morphology of different species was measured according to ph.calclation and discussion of the thermodynamic parameters were achieved. Both log K1 and –ΔH1, for M(II)-thiosemicarbazone complexes were found to be somewhat larger than log K2 and –ΔH2, demonstrating a shift in the dentate character of DMPTHP from tridentate in 1 : 1 chelates to bidentate in 1 : 2; M : L chelates and steric hindrance were generated by addition of the 2nd molecule. The compounds prepared have significant activity as antioxidants, similar to ascorbic acid. It is hoped that the results will be beneficial to antimicrobial agent chemistry. The formed compounds acted as a potent antibacterial agent. Molecular docking studies were investigated and have proved that DMPTHP as antibacterial agents act on highly resistant strains of E. coli and also as an anticancer agent.

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