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In vitro synthesis of nickel (II) complexes with amino acid Schiff base as potential anticancer drugs

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Document pages: 15 pages

Abstract: Three hexa coordinated octahedral nickel (II) complexes, [Ni (TRP SAL) (phen) (CH3OH)] (1), [Ni (trp-o-van) (phen) (CH3OH)] • 2ch3oh (2) and [Ni (TRP naph) (phen) (CH3OH)] (3) (TRP SAL is Schiff base derived from tryptophan and salicylaldehyde, trp-o-van is Schiff base derived from tryptophan and o-vanillin, TRP naph is Schiff base derived from tryptophan and 2-hydroxy-1-naphthaldehyde, and 1,10-phenanthroline is synthesized) The results show that three nitrogen atoms and three oxygen atoms meet the distorted octahedral environment around nickel (II) ions. These complexes show moderate cytotoxicity to esophageal cancer cellsine Eca-109 with the IC50 values of 23.95 ± 2.54 μM for 1, 18.14 ± 2.39 μM for 2, and 21.89 ± 3.19 μM for 3. Antitumor mechanism studies showed that complex 2 can increase the autophagy, reactive oxygen species (ROS) levels, and decrease the mitochondrial membrane potential remarkably in a dose-dependent manner in the Eca-109 cells. Complex 2 can cause cell cycle arrest in the G2 M phase. Additionally, complex 2 can regulate the Bcl-2 family and autophagy-related proteins.

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